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Recent Literature about Hemopure (HBOC-201)


A case study of 10 patients administered HBOC-201 in high doses over a prolonged period: Outcomes during severe anemia when transfusion is not an option.

Zumberg M, Gorlin J, Griffiths EA, et al. Transfusion. 2020. March (Article in press)


Renal Protection Against Ischemia Reperfusion Injury: Hemoglobin-based Oxygen Carrier-201 Versus Blood as an Oxygen Carrier in Ex Vivo Subnormothermic Machine Perfusion. Bhattacharjee RN, Patel SVB, Sun Q, et al.

Transplantation. 2020 Mar;104(3):482-489. doi: 10.1097/TP.0000000000002967.


Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies.

Raigani S, Karimian N, Huang V, et. al.

PLoS One. 2020 Jan 24;15(1):e0228011. doi: 10.1371/journal.pone.0228011. eCollection 2020.


Ex-Vivo Normothermic Limb Perfusion With a Hemoglobin-Based Oxygen Carrier Perfusate.

Said SA, Ordeñana CX, Rezaei M,

Mil Med. 2020 Jan 7;185(Supplement_1):110-120. doi:10.1093/milmed/usz314. PubMed PMID: 32074378.


The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model.

Mahboub P, Aburawi M, Karimian N, Lin F, et al.

Artif Organs. 2020 Jan;44(1):81-90. doi: 10.1111/aor.13534. Epub 2019 Aug 1.


The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-based oxygen carrier: The cold-to-warm machine perfusion of the liver.

Boteon YL, Laing RW, Schlegel A, et al.

PLoS One. 2019 Oct 23;14(10):e0224066. doi: 10.1371/journal.pone.0224066. eCollection 2019. Erratum in: PLoS One. 2020 Feb 27;15(2):e0230062.


Successful management of the potentially fatal hyperhaemolysis syndrome of sickle cell anaemia with a regimen including bortezomib andHemopure.

Epstein SS, Hadley TJ.

J Clin Pharm Ther. 2019 Oct;44(5):815-818. doi: 10.1111/jcpt.12998. Epub 2019 Jun 25.


Relative Efficacies of HBOC-201 and Polyheme to Increase Oxygen Transport Compared to Blood and Crystalloids.

Dubé GP, Pitman AN, Mackenzie CF.

Shock. 2019 Oct;52(1S Suppl 1):100-107. doi: 10.1097/SHK.0000000000001058.


Users Guide to Pitfalls and Lessons Learned About HBOC-201 During Clinical Trials, Expanded Access, and Clinical Use in 1,701 Patients.

Mackenzie CF, Dubé GP, Pitman A, Zafirelis M.

Shock. 2019 Oct;52(1S Suppl 1):92-99. doi: 10.1097/SHK.0000000000001038.


Selective aortic arch perfusion with fresh whole blood or HBOC-201 reverses hemorrhage-induced traumatic cardiac arrest in a lethal model of noncompressible torso hemorrhage.

Hoops HE, Manning JE, Graham TL, et al.

J Trauma Acute Care Surg. 2019 Aug;87(2):263-273. doi: 10.1097/TA.0000000000002315.


Freeze-dried plasma mitigates the dilution effects of a hemoglobin-based oxygen carrier (HBOC-

201) in a model of resuscitation for hemorrhage and hemodilution.

Meledeo MA, Peltier GC, McIntosh CS,

J Trauma Acute Care Surg. 2019 Jul;87(1S Suppl 1):S83-S90. doi: 10.1097/TA.0000000000002317.


Anti-N and anti-Doa immunoglobulin G alloantibody-mediated delayed hemolytic transfusion reaction with hyperhemolysis in sickle celldisease treated with eculizumab and HBOC-201: case report and review of the literature.

Unnikrishnan A, Pelletier JPR, Bari S, et al.

Transfusion. 2019 Jun;59(6):1907-1910. doi: 10.1111/trf.15198. Epub 2019 Feb 15.


Selective Aortic Arch Perfusion with fresh whole blood or HBOC-201 reverses hemorrhage-induced traumatic cardiac arrest in a lethal model of non-compressible torso hemorrhage.

Hoops HE, Manning JE, Graham TL, et al.J Trauma Acute Care Surg. 2019 Apr 18. doi: 10.1097/TA.0000000000002315. [Epub ahead of print]


Restoration of brain circulation and cellular functions hours post-mortem.

Vrselja Z, Daniele SG, Silbereis J, et al.

Nature. 2019 Apr;568(7752):336-343. doi: 10.1038/s41586-019-1099-1. Epub 2019 Apr 17.


Pharmacotherapy in Acutely Anemic Jehovah’s Witnesses: An Evidence-Based Review.

McConachie SM, Almadrahi Z, Wahby KA, et al.

Ann Pharmacother. 2018 Sep;52(9):910-919. doi: 10.1177/1060028018766656. Epub 2018 Mar 28.



Normothermic machine perfusion of donor livers without the need for human blood products.

Matton APM, Burlage LC, van Rijn R, et al.

Liver Transpl. 2018 Apr;24(4):528-538. doi: 10.1002/lt.25005. Erratum in: Liver Transpl. 2018 Aug;24(8):1151.


Use of the blood substitute HBOC-201 in critically ill patients during sickle crisis: a three-case series.

Davis JM, El-Haj N, Shah NN, et al.

Transfusion. 2018 Jan;58(1):132-137. doi: 10.1111/trf.14386. Epub 2017 Oct 26.


The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion.

Laing RW, Bhogal RH, Wallace L, et al.

Transplantation. 2017 Nov;101(11):2746-2756. doi: 10.1097/TP.0000000000001821.


Hemoglobin-Based Oxygen Carrier Rescues Double-Transplant Patient From Life-Threatening Anemia.

Gomez MF, Aljure O, Ciancio G, Lynn M.

Am J Transplant. 2017 Jul;17(7):1941-1944. doi: 10.1111/ajt.14226. Epub 2017 Mar 17.


Normalization of hemoglobin-based oxygen carrier-201 induced vasoconstriction: targeting nitric oxide and endothelin.

Taverne YJ, de Wijs-Meijler D, Te Lintel Hekkert M, et al.

J Appl Physiol (1985). 2017 May 1;122(5):1227-1237. doi: 10.1152/japplphysiol.00677.2016. Epub 2017 Feb 9.


Bloodless reperfusion with the oxygen carrier HBOC-201 in acute myocardial infarction: a novel platform for cardioprotective probesdelivery.

Garcia-Ruiz JM, Galan-Arriola C, Fernandez-Jimenez, et al.

Basic Res Cardiol. 2017 Mar;112(2):17. doi: 10.1007/s00395-017-0605-6. Epub 2017 Feb 10.


Hemoglobin glutamer-250 (bovine) in South Africa: consensus usage guidelines from clinician experts who have treated patients.

Mer M, Hodgson E, Wallis L, et al.

Transfusion. 2016 Oct;56(10):2631-2636. doi: 10.1111/trf.13726. Epub 2016 Sep 23.


Difficult to swallow: warm autoimmune hemolytic anemia in a Jehovah’s Witness treated with hemoglobin concentrate complicated byachalasia.

Epperla N, Strouse C, VanSandt AM, Foy P.

Transfusion. 2016 Jul;56(7):1801-6. doi: 10.1111/trf.13607. Epub 2016 Apr 6.


Hemoglobin-based oxygen carriers: disclosed history and the way ahead: the relativity of safety.

Weiskopf RB.

Anesth Analg. 2014 Oct;119(4):758-60. doi: 10.1213/ANE.0000000000000401. No abstract available.


A safety and efficacy evaluation of hemoglobin-based oxygen carrier HBOC-201 in a randomized, multicenter red blood cell controlled trial in noncardiac surgery patients.

Van Hemelrijck J, Levien LJ, Veeckman L, et al.

Anesth Analg. 2014 Oct;119(4):766-76. doi: 10.1213/ANE.0000000000000305.


Effects of a hemoglobin-based oxygen carrier (HBOC-201) and derivatives with altered oxygen affinity and viscosity on systemic and microcirculatory variables in a top-load rat model.

Song BK, Nugent WH, Moon-Massat PF, Pittman RN.

Microvasc Res. 2014 Sep;95:124-30. doi: 10.1016/j.mvr.2014.07.005. Epub 2014 Jul 18.


Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood.

Ortiz D, Barros M, Yan S, Cabrales P.

Am J Emerg Med. 2014 Mar;32(3):248-55. doi: 10.1016/j.ajem.2013.11.045. Epub 2013 Dec 7.


Experience with the use of Hemopure in the care of a massively burned adult.

Lundy JB, Lewis CJ, Cancio LC, Cap AP.

Int J Burns Trauma. 2014 Feb 22;4(1):45-8. eCollection 2014.


Hypertonic HBOC-201 decreases neutrophil activation after hemorrhagic shock.

Rivera-Chavez FA, Lu A, Liu MM, et al.

J Invest Surg. 2014 Feb;27(1):14-20. doi: 10.3109/08941939.2013.826756.


Bovine hemoglobin: a nontraditional approach to the management of acute anemia in a Jehovah’s Witness patient with autoimmune hemolytic anemia.

Jordan SD, Alexander E.

J Pharm Pract. 2013 Jun;26(3):257-60. doi: 10.1177/0897190012451928. Epub 2012 Aug 6.


New and future resuscitation fluids for trauma patients using hemoglobin and hypertonic saline.

Galvagno SM Jr, Mackenzie CF.

Anesthesiol Clin. 2013 Mar;31(1):1-19. doi: 10.1016/j.anclin.2012.10.004. Epub 2012 Dec 6. Review.


Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products.

Jahr JS, Akha AS, Holtby RJ.

Curr Drug Discov Technol. 2012 Sep;9(3):158-65. Review.


The effect HBOC-201 and sodium nitrite resuscitation after uncontrolled haemorrhagic shock in swine.

Moon-Massat P, Scultetus A, Arnaud F, et al.

Injury. 2012 May;43(5):638-47. doi: 10.1016/j.injury.2010.10.013. Epub 2010 Nov 20.


Traumatic brain injury and severe uncontrolled haemorrhage with short delay pre-hospital resuscitation in a swine model.

Teranishi K, Scultetus A, Haque A, et al.

Injury. 2012 May;43(5):585-93. doi: 10.1016/j.injury.2010.09.042. Epub 2010 Oct 30.


Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine.

Haque A, Arnaud F, Teranishi K, et al.

Artif Cells Blood Substit Immobil Biotechnol. 2012 Feb;40(1-2):44-55. doi: 10.3109/10731199.2011.585615. Epub 2011 Aug 2.


Dose response of sodium nitrite on vasoactivity associated with HBOC-201 in a swine model of controlled hemorrhage.

Arnaud F, Scultetus AH, Kim B, et al.

Artif Cells Blood Substit Immobil Biotechnol. 2011 Aug;39(4):195-205. doi: 10.3109/10731199.2010.533126. Epub 2010 Dec 6.


A bovine hemoglobin-based oxygen carrier as pump prime for cardiopulmonary bypass: reduced systemic lactic acidosis and improved cerebral oxygen metabolism during low flow in a porcine model.

McNeil JD, Propper B, Walker J, et al.

J Thorac Cardiovasc Surg. 2011 Aug;142(2):411-7. doi: 10.1016/j.jtcvs.2010.11.017.


Vital organ tissue oxygenation after serial normovolemic exchange transfusion with HBOC-201 in anesthetized swine.

Muir WW, Ilangovan G, Zweier JL, et al.Shock. 2011 Jun;35(6):597-603. doi: 10.1097/SHK.0b013e31821366f6.


A synthetic haemoglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma.

Fitzgerald MC, Chan JY, Ross AW, et al. Med J Aust. 2011 May 2;194(9):471-3.


US Navy experience with research on, and development of, hemoglobin-based oxygen carriers.

Auker CR, McCarron RM.

J Trauma. 2011 May;70(5 Suppl):S40-1. doi: 10.1097/TA.0b013e31821a5a1e. Review. No abstract available.


Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage.

Scultetus A, Arnaud F, Kaplan L, Shander A, et al.


Artif Cells Blood Substit Immobil Biotechnol. 2011 Apr;39(2):59-68. doi: 10.3109/10731199.2010.501755. Epub 2010 Jul 20.


Reconstructing hemoglobin-based oxygen carriers.

Greenburg AG, Light WR, Dubé GP.

Transfusion. 2010 Dec;50(12):2764-7; author reply 2767. doi: 10.1111/j.1537-2995.2010.02814.x. No abstract available.


Management of acute anemia in a Jehovah’s Witness patient with acute lymphoblastic leukemia with polymerized bovine hemoglobin-based oxygen carrier: a case report and review of literature. Donahue LL, Shapira I, Shander A, et al.

Transfusion. 2010 Jul;50(7):1561-7. doi: 10.1111/j.1537-2995.2010.02603.x. Epub 2010 Apr 23.



Differential sensitivities of pulmonary and coronary arteries to hemoglobin-based oxygen carriers and nitrovasodilators: study in a bovine ex vivo model of vascular strips.

Fonseca V, Avizinis J, Moon-Massat P, et al.

Vascul Pharmacol. 2010 May-Jun;52(5-6):215-23. doi: 10.1016/j.vph.2009.12.005. Epub 2009 Dec 22.


Nitroglycerin attenuates vasoconstriction of HBOC-201 during hemorrhagic shock resuscitation.

Katz LM, Manning JE, McCurdy S, et al.

Resuscitation. 2010 Apr;81(4):481-7. doi: 10.1016/j.resuscitation.2009.12.015. Epub 2010 Jan 18.


Preoxygenated hemoglobin-based oxygen carrier HBOC-201 annihilates myocardial ischemia during brief coronary artery occlusion in pigs.

Te Lintel Hekkert M, Dubé GP, Regar E, et al.

Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1103-13. doi: 10.1152/ajpheart.00667.2009. Epub 2010 Jan 8.


Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter study.

Jahr JS, Liu H, Albert OK, et al.

Am J Ther. 2010 Mar-Apr;17(2):140-7. doi: 10.1097/MJT.0b013e3181a2b08d.


Hemoglobin-based oxygen carriers: compassionate use and compassionate clinical trials.

Weiskopf RB.

Anesth Analg. 2010 Mar 1;110(3):659-62. doi: 10.1213/ANE.0b013e3181c85255. No abstract available.


When blood is not an option: factors affecting survival after the use of a hemoglobin-based oxygen carrier in 54 patients with life-threatening anemia.

Mackenzie CF, Moon-Massat PF, Shander A, et al

Anesth Analg. 2010 Mar 1;110(3):685-93. doi: 10.1213/ANE.0b013e3181cd473b.


Effects of hemodilution with a hemoglobin-based oxygen carrier (HBOC-201) on ischemia/reperfusion injury in a model of partial warm liver ischemia of the rat. Zapletal C, Bode A, Lorenz MW, et al.

Microvasc Res. 2009 Dec;78(3):386-92. doi: 10.1016/j.mvr.2009.08.005. Epub 2009 Aug 26.


HBOC-201 use in traumatic brain injury: case report and review of literature.

Marinaro J, Smith J, Tawil I, et al.


Transfusion. 2009 Oct;49(10):2054-9. doi: 10.1111/j.1537-2995.2009.02235.x. Epub 2009 May 27.



Regional blood flow after serial normovolemic exchange transfusion with HBOC-201 (Hemopure) in anesthetized swine.

Mongan PD, Moon-Massat PF, Rentko V, et al.

J Trauma. 2009 Jul;67(1):51-60. doi: 10.1097/TA.0b013e3181838030.


HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects–extrapolation of potential risk for acute trauma trials.

Freilich D, Pearce LB, Pitman A, et al.

J Trauma. 2009 Feb;66(2):365-76. doi: 10.1097/TA.0b013e3181820d5c.


Blood alternative products: correction regarding Jehovah’s Witnesses.

Muller CF.

S Afr Med J. 2009 Feb;99(2):72, 74; author reply 74. No abstract available.


Resuscitation with the hemoglobin-based oxygen carrier, HBOC-201, in a swine model of severe uncontrolled hemorrhage and traumatic brain injury.

Stern S, Rice J, Philbin N, McGwin G, et al.

Shock. 2009 Jan;31(1):64-79. doi: 10.1097/SHK.0b013e3181778dc3.


Management of hemorrhagic shock when blood is not an option.

Mackenzie CF, Morrison C, Jaberi M, et al.

J Clin Anesth. 2008 Nov;20(7):538-41. doi: 10.1016/j.jclinane.2008.05.012. Epub 2008 Nov 18.


Hematologic effects of recombinant factor VIIa combined with hemoglobin-based oxygen carrier- 201 for prehospital resuscitation of swine with severe uncontrolled hemorrhage due to liver injury. Arnaud F, Hammett M, Philbin N, et al.

Blood Coagul Fibrinolysis. 2008 Oct;19(7):669-77. doi: 10.1097/MBC.0b013e3283089198.


Hemoglobin-based oxygen carrying compound-201 as salvage therapy for severe neuro- and polytrauma (Injury Severity Score = 27-41).

Dudkiewicz M, Harpaul TA, Proctor KG.

Crit Care Med. 2008 Oct;36(10):2838-48. doi: 10.1097/CCM.0b013e318186f6b3.


Bovine blood and neuromuscular paralysis as a bridge to recovery in a patient with severe autoimmune hemolytic anemia.

Pachinburavan M, Marik PE.

Clin Transl Sci. 2008 Sep;1(2):172-3. doi: 10.1111/j.1752-8062.2008.00006.x.


Innate immune response after resuscitation with hemoglobin-based oxygen carrier and recombinant factor VIIA in uncontrolled hemorrhagic shock in a swine model. Malkevich NV, Dong F, Vandermolen CA, et al

J Trauma. 2008 Jun;64(6):1498-510. doi: 10.1097/TA.0b013e3181454a05.


HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedicsurgery.

Jahr JS, Mackenzie C, Pearce LB, et al.

J Trauma. 2008 Jun;64(6):1484-97. doi: 10.1097/TA.0b013e318173a93f.


HBOC-201: the multi-purpose oxygen therapeutic. Dubé GP, Vranckx P, Greenburg AG. EuroIntervention. 2008 May;4(1):161-5. Review.


Proof-of-concept trial to evaluate haemoglobin based oxygen therapeutics in elective percutaneous coronary revascularisation. Rationale, protocol design and haemodynamic results.

Meliga E, Vranckx P, Regar E, et al. EuroIntervention. 2008 May;4(1):99-107.


The effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers in swine with hemorrhagicshock.

Rice J, Philbin N, Light R, et al.

J Trauma. 2008 May;64(5):1240-57. doi: 10.1097/TA.0b013e318058245e.


Haemoglobin, oxygen carriers and perioperative organ perfusion.

Kocian R, Spahn DR.

Best Pract Res Clin Anaesthesiol. 2008 Mar;22(1):63-80. Review.


Haemodynamic effects, safety, and tolerability of haemoglobin-based oxygen carrier-201 in patients undergoing PCI for CAD.

EuroIntervention. 2008 Mar;3(5):600-9. Serruys PW, Vranckx P, Slagboom T, et al.


Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigation.

Rosenthal G, Morabito D, Cohen M, et al..

J Neurosurg. 2008 Mar;108(3):575-87. doi: 10.3171/JNS/2008/108/3/0575.


Resuscitation from hemorrhagic shock comparing standard hemoglobin-based oxygen carrier (HBOC)-201 versus 7.5% hypertonic HBOC-201.

Rivera-Chavez FA, Huerta S, Brown R, et al. J Trauma. 2007 Nov;63(5):1113-9.


Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care.

Arnaud F, Fasipe D, Philbin N, et al. Transfusion. 2007 Nov;47(11):2098-109.


Blood substitutes as pharmacotherapies in clinical practice.

Jahr JS, Walker V, Manoochehri K.

Curr Opin Anaesthesiol. 2007 Aug;20(4):325-30. Review.


Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobinbased oxygen carrier as an oxygen bridge to definitive care.

Philbin N, Handrigan M, Rice J, et al.

Resuscitation. 2007 Aug;74(2):332-43. Epub 2007 Mar 23.


Hemoglobin-based O2 carrier O2 affinity and capillary inlet pO2 are important factors that influence O2 transport in a capillary.


Dimino ML, Palmer AF.

Biotechnol Prog. 2007 Jul-Aug;23(4):921-31. Epub 2007 Jun 8.


Hemopure transfusion in a child with severe anemia.

Stefan DC, Uys R, Wessels G.

Pediatr Hematol Oncol. 2007 Jun;24(4):269-73.


Resuscitation from hemorrhagic shock with HBOC-201 in the setting of traumatic brain injury.

Kerby JD, Sainz JG, Zhang F, et al. Shock. 2007 Jun;27(6):652-6.


Effects of Hemopure on maximal oxygen uptake and endurance performance in healthy humans.

Ashenden MJ, Schumacher YO, Sharpe K, et al.

Int J Sports Med. 2007 May;28(5):381-5. Epub 2006 Oct 6.


Bovine hemoglobin (glutamer-250, Hemopure)-specific immunoglobulin G antibody cross-reacts with human hemoglobin but does not lyse red blood cells in vitro.

Hamilton RG, Kickler TS. Transfusion. 2007 Apr;47(4):723-8.


Innate immune responses in Swine resuscitated from severe traumatic hemorrhagic shock with hemoglobin-based oxygen carrier-201.

Hall C, Malkevich N, Handrigan M, et al.

Artif Cells Blood Substit Immobil Biotechnol. 2007;35(3):259-74.


Vasoactivity of bovine polymerized hemoglobin (HBOC-201) in swine with traumatic hemorrhagic shock with and without brain injury.

Rice J, Philbin N, Handrigan M, Hall C, et al. J Trauma. 2006 Nov;61(5):1085-99.


Oxygen therapeutics: oxygen delivery without blood.

Stollings JL, Oyen LJ.

Pharmacotherapy. 2006 Oct;26(10):1453-64. Review.


A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardialischemia.

George I, Yi GH, Schulman AR, et al.

Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1126-37. Epub 2006 Apr 14.


Bovine polymerized hemoglobin versus Hextend resuscitation in a swine model of severe controlled hemorrhagic shock with delay to definitive care.

Rice J, Philbin N, McGwin G, et al. Shock. 2006 Sep;26(3):302-10.


Coagulation patterns following haemoglobin-based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swine.

Arnaud F, Handrigan M, Hammett M, et al. Transfus Med. 2006 Aug;16(4):290-302.


Resuscitation from hemorrhagic shock: fluid selection and infusion strategy drives unmeasured ion genesis.

Kaplan LJ, Philbin N, Arnaud F, et al.


J Trauma. 2006 Jul;61(1):90-7; discussion 97-8.


Prehospital HBOC-201 after traumatic brain injury and hemorrhagic shock in swine.

Patel MB, Feinstein AJ, Saenz AD, et al. J Trauma. 2006 Jul;61(1):46-56.


Acute and long-term effects of modified hemoglobin (HBOC-201) in a rat model of hypertension and chronic kidney disease.

Baylis C.

Transfusion. 2006 Jul;46(7):1104-11.


Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation–effects on histopathology and organ function.

Johnson T, Arnaud F, Dong F, et al.

Crit Care Med. 2006 May;34(5):1464-74.


A comparison of the acute hemodynamic and delayed effects of 50% exchange transfusion with two different cross-linked hemoglobin based oxygen carrying solutions and Pentastarch. Bonegio RG, Fuhro R, Ragno G, et al.

Artif Cells Blood Substit Immobil Biotechnol. 2006;34(2):145-57.


Bovine hemoglobin-based oxygen-carrying solution (HBOC-201) improves flap survival in a rat model of epigastric flap failure.

Microsurgery. 2006;26(3):203-6.

Ortegon DP, Davis MR, Sampson JB, et al.


Immune effects of resuscitation with HBOC-201, a hemoglobin-based oxygen carrier, in swine with moderately severe hemorrhagic shock from controlled hemorrhage.

Dong F, Hall CH, Golech SA, et al. Shock. 2006 Jan;25(1):50-5.


Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201.

Freitag M, Standl TG, Gottschalk A, et al. Can J Anaesth. 2005 Nov;52(9):904-14.


Long-term transfusion of polymerized bovine hemoglobin in a Jehovah’s Witness following chemotherapy for myeloid leukemia: a case report.

Agrawal YP, Freedman M, Szczepiorkowski ZM. Transfusion. 2005 Nov;45(11):1735-8.


A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation.

Philbin N, Rice J, Gurney J, et al. Resuscitation. 2005 Sep;66(3):367-78.


[Artificial oxygen carriers as an alternative to red blood cell transfusion].

Habler O, Pape A, Meier J, Zwissler B.

Anaesthesist. 2005 Aug;54(8):741-54. Review. German.


Prolonged low-volume resuscitation with HBOC-201 in a large-animal survival model of controlled hemorrhage.


Fitzpatrick CM, Biggs KL, Atkins BZ, et al.

J Trauma. 2005 Aug;59(2):273-81; discussion 281-3.

Effects of bovine polymerized hemoglobin on coagulation in controlled hemorrhagic shock in swine.

Arnaud F, Hammett M, Asher L, et al. Shock. 2005 Aug;24(2):145-52.


Cardioprotection before revascularization in ischemic myocardial injury and the potential role of hemoglobin-based oxygen carriers.

Burkhoff D, Lefer DJ.

Am Heart J. 2005 Apr;149(4):573-9. Review.


A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury.

Caswell JE, Strange MB, Rimmer DM, et al

Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1796-801.


Artificial O2 carriers: status in 2005.

Spahn DR, Kocian R.

Curr Pharm Des. 2005;11(31):4099-114. Review.


Hemopure’s process demonstrates TSE and viral clearance.

Laccetti A, Bagai J, Gawryl MS, Light WR.

Dev Biol (Basel). 2005;120:35-6. No abstract available.


The effect of hemopure on coagulation in clinically relevant concentrations.

James MF, Potgieter HE, Ellis P.

Anesth Analg. 2004 Dec;99(6):1593-7, table of contents.


Resuscitation with a blood substitute causes vasoconstriction without nitric oxide scavenging in a model of arterial hemorrhage.

Fitzpatrick CM, Savage SA, Kerby JD, et al. J Am Coll Surg. 2004 Nov;199(5):693-701.


Hemoglobin substitutes.

Anbari KK, Garino JP, Mackenzie CF.

Eur Spine J. 2004 Oct;13 Suppl 1:S76-82. Epub 2004 May 27. Review.


A hemoglobin based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus Hetastarch (HEX) in an uncontrolled liver injury hemorrhagic shock swine model with delayed evacuation. Gurney J, Philbin N, Rice J, et al.

J Trauma. 2004 Oct;57(4):726-38.


Hope for reducing SA’s trauma deaths?

Bateman C.

S Afr Med J. 2004 Sep;94(9):728-9. No abstract available.


The use of a hemoglobin-based oxygen-carrying solution (HBOC-201) for extracorporeal membrane oxygenation in a porcine model with acute respiratory distress syndrome.

Henderson CL, Anderson CM, Sorrells DL, et al. Pediatr Crit Care Med. 2004 Jul;5(4):384-90.


The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding.

Marret E, Bonnin P, Mazoyer E, et al.

Anesth Analg. 2004 Mar;98(3):604-10, table of contents.


Hemoglobin-based oxygen carriers.

Greenburg AG, Kim HW.

Crit Care. 2004;8 Suppl 2:S61-4. Epub 2004 Jun 14. Review.


Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage.

York GB, Eggers JS, Smith DL, et al. J Trauma. 2003 Nov;55(5):873-85.


The effect of the bovine hemoglobin oxygen therapeutic HBOC-201 on human neutrophil activation in vitro.

Ortegon DP, Dixon PS, Crow KK, et al.

J Trauma. 2003 Oct;55(4):755-60; discussion 760-1.


A comparison of the hemoglobin-based oxygen carrier HBOC-201 to other low-volume resuscitation fluids in a model of controlled hemorrhagic shock.

Sampson JB, Davis MR, Mueller DL, et al. J Trauma. 2003 Oct;55(4):747-54.


The use of haemoglobin glutamer-250 (HBOC-201) as an oxygen bridge in patients with acute anaemia associated with surgical blood loss.

Levy JH.

Expert Opin Biol Ther. 2003 Jun;3(3):509-17. Review. Erratum in: Expert Opin Biol Ther. 2003 Sep;3(6):1017.


Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored red blood cells.

Standl T, Freitag M, Burmeister MA, et al. J Vasc Surg. 2003 Apr;37(4):859-65.


Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated Ringer’s solution, hypertonic saline dextran, and HBOC-201.

Knudson MM, Lee S, Erickson V, et al. J Trauma. 2003 Feb;54(2):242-52.


Small-volume resuscitation with the hemoglobin substitute HBOC-201: effect on brain tissue oxygenation.

Manley GT, Hemphill JC, Morabito D, et al. Adv Exp Med Biol. 2003;530:311-7.


The pharmacology of tissue oxygenation by biopure’s hemoglobin-based oxygen carrier, Hemopure (HBOC-201).

Pearce LB, Gawryl MS.

Adv Exp Med Biol. 2003;530:261-70.


The polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) is not toxic to neural cells in culture.

Ortegon DP, Davis MR, Dixon PS, et al. J Trauma. 2002Dec;53(6):1068-72.


Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine.

Lee SK, Morabito D, Hemphill JC, et al. Acad Emerg Med. 2002 Oct;9(10):969-76.


Extracorporeal membrane oxygenation in piglets using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201).

York GB, DiGeronimo RJ, Wilson BJ, et al. J Pediatr Surg. 2002 Oct;37(10):1387-92.


Severe anemia after gastrointestinal hemorrhage in a Jehovah’s Witness: new treatment strategies.

Gannon CJ, Napolitano LM.

Crit Care Med. 2002 Aug;30(8):1893-5.


Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial.

Levy JH, Goodnough LT, Greilich PE, et al.

J Thorac Cardiovasc Surg. 2002 Jul;124(1):35-42.


HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury.

Katz LM, Manning JE, McCurdy S, et al. Resuscitation. 2002 Jul;54(1):77-87.


Potential of hemoglobin-based oxygen carriers in trauma patients.

Arnoldo BD, Minei JP.

Curr Opin Crit Care. 2001 Dec;7(6):431-6. Review.


Selective aortic arch perfusion with hemoglobin-based oxygen carrier-201 for resuscitation from exsanguinating cardiac arrest in swine.

Manning JE, Katz LM, Pearce LB, et al. Crit Care Med. 2001Nov;29(11):2067-74.


The successful use of hemoglobin-based oxygen carrier as a primary blood substitute during abdominal aneurysm repair with large blood loss.

Sprung J, Popp H, O’Hara P, et al. Anesth Analg. 2001 Jun;92(6):1413-5.


Hypotensive resuscitation using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) leads to reversal of anaerobicmetabolism.

McNeil CJ, Smith LD, Jenkins LD, et al. J Trauma. 2001 Jun;50(6):1063-75.


Absence of immunopathology associated with repeated IV administration of bovine Hb-based oxygen carrier in dogs.

Hamilton RG, Kelly N, Gawryl MS, et al. Transfusion. 2001 Feb;41(2):219-25.


Transfusions of polymerized bovine hemoglobin in a patient with severe autoimmune hemolytic anemia.

Mullon J, Giacoppe G, Clagett C, et al.

N Engl J Med. 2000 Jun 1;342(22):1638-43.


The reduction of the allogenic transfusion requirement in aortic surgery with a hemoglobin-based solution.

LaMuraglia GM, O’Hara PJ, Baker WH, et al. J Vasc Surg. 2000 Feb;31(2):299-308.


Bovine hemoglobin-based oxygen carrier (HBOC-201) for resuscitation of uncontrolled, exsanguinating liver injury in swine. Carolina Resuscitation Research Group.

Manning JE, Katz LM, Brownstein MR, et al. Shock. 2000 Feb;13(2):152-9.


Administration of polymerized bovine hemoglobin improves survival in a rat model of traumatic shock.

Hayward R, Lefer AM.

Methods Find Exp Clin Pharmacol. 1999 Jul-Aug;21(6):427-33.


Bovine haemoglobin-based oxygen carrier for patients undergoing haemodilution before liver resection.

Standl T, Burmeister MA, Horn EP, et al. Br J Anaesth. 1998 Feb;80(2):189-94.


A phase I/II study of polymerized bovine hemoglobin in adult patients with sickle cell disease not in crisis at the time of study.

Gonzalez P, Hackney AC, Jones S, et al. J Investig Med. 1997 Jun;45(5):258-64.


Effects of a hemoglobin-based oxygen carrier (HBOC-201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery.

Kasper SM, Walter M, GrÃne F,et al. Anesth Analg. 1996 Nov;83(5):921-7.


Hemoglobin-based oxygen carrier preserves submaximal exercise capacity in humans.

Hughes GS Jr, Yancey EP, Albrecht R, et al. Clin Pharmacol Ther. 1995 Oct;58(4):434-43.

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